ICMR-Regional Medical Research Centre established on 29th March, 1981 is one of the 27 center of ICMR in Bhubaneswar, Odisha. In the last four decades the Centre has focused its activities on research in both communicable and non-communicable diseases, human resource development programme and establishing strong linkage with different departments of State government in finding solutions to the regional public health problem. Besides basic and applied research, translational research has been taken up in operational mode. Communicable research programme includes studies on lymphatic filariasis, malarial, diarrhoeal diseases, tuberculosis, diseases of viral etiology and zoonotic diseases. Non communicable diseases include multimorbidity, nutrition, sickle cell disease, hypertension and diabetes.